NODULAR ADRENAL-HYPERPLASIA (NAH) - RECUR RENCE OF CUSHINGS-SYNDROME FOLLOWING SUCCESSFUL PITUITARY MICROADENECTOMY

Long-lasting stimulation by adrenocorticotropic hormone (ACTH) due to pituitary adenoma may cause nodular enlargement in the adrenal cortex. This nodule may function autonomously and cause ACTH-independent Gush ing's syndrome. We present two cases of recurrent Gushing's syndrome f ollowing successful pituitary microadenectomy (with positive histopath ology and postoperative decrease of ACTH). Both were treated with bila teral adrenalectomy and histopathology revealed macronodular adrenal h yperplasia. Gushing's syndrome was cured after bilateral adrenalectomy in both patients.