Percutaneous transhepatic cholangioscopy (PTCS) was performed in 53 pa
tients. Biopsies of suspected malignancies of the extrahepatic biliary
system yielded false negative results in 22.7%, those of Klatskin tum
ours in 33.4% (in contrast to 25% and 16%, respectively, for brush cyt
ology). Moreover, PTCS was used for implantation and revision of stent
s: Occlusions of implants were due to granulation tissue in about the
same number of cases as in overgrowth of tumour. Bleeding without a ne
cessity for therapy was seen six times; one patient developed hemobili
a. In spite of the relatively high number of false negative results in
malignancies, for suitable indications PTCS is a valuable supplementa
ry diagnostic and therapeutic procedure.