EXPRESSION OF PLASMINOGEN-ACTIVATOR INHIBITOR-2 IN THE ADULT AND EMBRYONIC MOUSE-TISSUES

We have studied the expression of plasminogen activator inhibitor 2 (P AI-2) in the adult mouse and during embryonic development using immuno histochemistry and the polymerase-chain reaction. Mouse PAI-2 mRNA was mainly expressed in the skin, bone-marrow, spleen, lung, thymus, and urinary bladder. Immunohistochemical studies suggested that PAI-2 was synthesized in macrophages and epithelial cells such as skin epithelia l cells, transitional cells of the urinary bladder, and mesothelial ce ll of peritoneum and pleura. PAI-2 mRNA and antigen expression was obs erved only in the skin of 15 day-old mouse embryos. These data suggest that PAI-2 may play a role in protecting the mouse embryo from the pr otease attack in the amniotic fluid and also in maintaining and/or pro tecting the structure of various surfaces in the mouse.