DOSAGE SCHEDULES OF AMINOGLYCOSIDES

During the past 8 years a large number of clinical studies have provid ed sufficient evidence that once-a-day dosing of aminoglycosides is pr eferable to the conventional multiple-dairy dosing. Certain patient ca tegories (children, neutropenic patients, cystic fibrosis patients) an d specific infections (endocarditis) have, however, not been extensive ly evaluated. Other current issues with regard to once-a-day regimens are how to adjust the daily dose in patients with renal failure, and h ow to monitor therapy.