Standard management of the febrile neutropenic patient consists of the
administration of broad-spectrum antimicrobial agents after appropria
te evaluation. This is generally done within the confines of a hospita
l ward in order to maximize supportive care, and to detect and deal wi
th complications such as septic shock or superinfection as promptly as
possible, Not all febrile neutropenic patients have the same risk for
developing complications. Recently, developed risk assessment strateg
ies can help identify 'low-risk' patients at the onset of febrile epis
odes. These low-risk patients can be treated in the outpatient setting
using parenteral, sequential, or oral antimicrobial regimens, resulti
ng in a dramatic reduction in the cost of therapy, better resource uti
lization, and greater patient satisfaction as a result of an enhanced
quality of life.