The present communication focuses on a sociocultural perspective of su
bstance use in a pluralistic and diverse culture. India has a history
of use of plant products, viz., cannabis, opium, and home-brewed alcoh
olic beverages, within a defined sociocultural framework over five mil
lennium. Cross-sectional epidemiological studies in the field of subst
ance use in different parts of India show that certain social groups a
re more ''vulnerable'' to substance use. Caste, religion, and local cu
stoms and traditions play a significant role in the choice of drugs, t
heir consumption, and their control in rural/semiurban populations. Th
e intercultural barriers are diminishing in urban populations, and eve
n alien drugs like heroin have been introduced. The social and cultura
l implications of the traditional vis-a-vis the altering drug use scen
e are discussed at length.