BIODISTRIBUTION OF TRACE-ELEMENTS IN NORMAL, ALUMINUM-OVERLOADED AND CADMIUM-OVERLOADED MICE - AN APPLICATION OF THE RADIOACTIVE MULTITRACER TECHNIQUE

The radioactive multitracer technique was applied to simultaneous eval uation of biobehavior of many trace elements in normal, Al-overloaded and Cd-overloaded mice. The tissue and subcellular distributions of Be , Sc, V, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Ru, and Rh were examin ed by using a multitracer solution, prepared from an Ag target irradia ted with heavy ions, in 9 organs (brain, cardiac muscle, lung, liver, spleen, pancreas, kidney, skeletal muscle, and bone) and blood. Their tissue and subcellular distributions were evaluated by gamma-ray spect rometry in terms of tissue uptake rate (the radioactivity percentage o f injected dose per gram of tissue, percent of dose/g) and fractionati on percentage (the radioactivity percentage of nuclear fraction, mitoc hondrial fraction, microsomal fraction or supernatant fraction, percen t), respectively. Comparative biobehavior of these elements in brain a nd liver is reported. Aluminum- and Cd-induced synergistic interaction s were observed among these trace elements in their liver uptake behav ior.