MOLECULAR DETERMINANTS OF THE INTERACTION BETWEEN HAEMOPHILUS-INFLUENZAE AND HUMAN-CELLS

Haemophilus influenzae is a human-specific pathogen that must colonize the human upper respiratory tract to avoid extinction. On occasion, o rganisms penetrate the epithelial barrier and cause bacteremic disease or spread within the respiratory tract to produce localized disease. Attachment to host epithelium is fundamental to the process of coloniz ation and to the pathogenesis of disease. Accordingly, H. influenzae h as evolved to express a number of factors that promote interaction wit h human epithelial cells. Our current understanding of H. influenzae t ype b and nontypable H. Influenzae adhesins is reviewed in this report . In addition, models are proposed for the interrelationship of these molecules.