HETEROCYCLES DERIVED FROM -DIHYDROPYRIDAZIN-3-YLOXYMETHYL]-1,3,4-THIADIAZOLE

-dihydropyridazin-3-yloxymethyl]-1,3,4-thiadiazole (2) has been synthe sised by treating thiosemicarbazide with the acid 1. The amine (2) on treatment with aromatic aldehydes furnishes schiff bases of thiadiazol es (3a,b) which on reaction with thioglycollic acid yield 4-thiazolidi none derivatives (4a,b). Reaction of 2 with phenyl isocyanate and phen yl isothiocyanate give the corresponding aminocarbamide and aminocarbo thiamide derivatives (6 and 7), respectively, which on reaction with m alonic acid in acetyl chloride afford baribituric and thiobarbituric a cid derivatives (8a,b), respectively. However, reaction of carbon disu lphide and methyl iodide with 2 give dithiocarbamidate derivative (9) which on treatment with o-phenylenediamine and ethylenediamine give 10 and 11, respectively.