ANALYSIS OF SCHIZOPHRENIA LINKAGE WITH MA RKER LOCI OF CHROMOSOME-2 AND CHROMOSOME-11 IN RUSSIAN FAMILIES

Two molecular-genetic markers-H-ras and YNH24 (chromosome 2)-were test ed for genetic linkage with schizophrenia in eight Russian families wi th different forms of the disease. Thirty-nine subjects, including 13 affected ones, were examined. Five alleles represented as DNA fragment s from 2.4 to 4.0 kb in size were detected in DNA samples from proband s and other family members when the H-ras probe and TagI restriction e ndonuclease were used. Eleven alleles were identified in hybridization experiments with YNH24 as a probe. Linkage tests between marker allel es and the schizophrenia predisposition gene were performed by means o f the sib-pair method. Statistically significant evidence (5% signific ance level) for linkage between allele 2 of H-ras and the gene control ling predisposition to schizophrenia was found.