EFFECT OF PEROXYNITRITE ON ERYTHROCYTES

Authors
SOSZYNSKI M BARTOSZ G
Citation
M. Soszynski et G. Bartosz, EFFECT OF PEROXYNITRITE ON ERYTHROCYTES, Biochimica et biophysica acta (G). General subjects, 1291(2), 1996, pp. 107-114
Citations number
39
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta (G). General subjects → ACNP
ISSN journal
03044165
Volume
1291
Issue
2
Year of publication
1996
Pages
107 - 114
Database
ISI
SICI code
0304-4165(1996)1291:2<107:EOPOE>2.0.ZU;2-L
Abstract
The action of peroxynitrite on human erythrocytes and erythrocyte memb ranes was studied. Peroxynitrite (0.1-2 mM) induced a transient decrea se of intracellular reduced glutathione, oxidized membrane protein -SH groups, initiated membrane lipid peroxidation and inactivated erythro cyte membrane acetylcholinesterase and ATPase activities. Membranes ex posed to peroxynitrite showed aggregation and nitration of proteins an d changes in protein organization detectable with a maleimide spin lab el.