METABOLIC EFFECTS OF DIETARY SUCROSE AND FRUCTOSE IN TYPE-II DIABETICSUBJECTS

OBJECTIVE - Tb investigate the metabolic effects of dietary fructose a nd sucrose in type II diabetic patients. RESEARCH DESIGN AND METHODS - Sixteen well-controlled type II diabetic subjects were fed three isoc aloric diets for 28 days each. The three diets provided 50-55, 15, and 30-35% of total energy from carbohydrate, protein, and Fat, respectiv ely. In one diet, 20% of total calories were derived from fructose; in another, 19% of total calories were derived from sucrose; and in the control diet, only 5% of daily calories were derived from sugars, all other carbohydrates being supplied as polysaccharides. RESULTS - No si gnificant differences were observed between either the fructose or the sucrose diet and the control polysaccharide diet in any of the measur es of glycemic control, serum lipid levels, or insulin and C-peptide s ecretion.CONCLUSIONS - Our data suggest that in the short and middle t erms, high fructose and sucrose diets do not adversely affect glycemia , lipemia, or insulin and C-peptide secretion in well-controlled type II diabetic subjects.