ASYMPTOMATIC TRICYCLIC TOXICITY ASSOCIATED WITH DILTIAZEM

Citation
Pa. Cotter et al., ASYMPTOMATIC TRICYCLIC TOXICITY ASSOCIATED WITH DILTIAZEM, Irish journal of psychological medicine, 13(4), 1996, pp. 168-169
Citations number
22
Categorie Soggetti
Psychology
ISSN journal
07909667
Volume
13
Issue
4
Year of publication
1996
Pages
168 - 169
Database
ISI
SICI code
0790-9667(1996)13:4<168:ATTAWD>2.0.ZU;2-S
Abstract
Therapeutic drug monitoring of tricyclic antidepressants is a controve rsial issue, A case is reported in which a patient with recurrent depr ession developed asymptomatic tricyclic toxicity while on trimipramine , a tricyclic antidepressant, and diltiazem, a calcium channel blocker A metabolic interaction involving cytochrome P450 3A (CYP3A) is postu lated. It is suggested that routine therapeutic drug monitoring of tri cyclic levels should be an essential part of the management of depress ion.