THE ROLE OF THE CELL-CYCLE IN GENITOURINARY CARCINOMA

The understanding of the cell cycle and the control of cellular prolif eration has increased dramatically over the past years. Cancer is most likely caused by multiple genetic aberrations, therefore it seems lik ely that one or more genes involved in tumorigenesis will regulate a p ortion of the cell cycle. Cell cycle related genes, such as p53 are be coming important in determining prognosis. In addition, gene replaceme nt therapy for a deleted gene may hold promise in treating malignancie s. Further understanding of cell proliferation should bring may ked im provements in the diagnosis and treatment of genitourinary malignancie s.