COMPACTION PROPERTIES OF MELT COATED COARSE DRUG PARTICLES

Xylitol and stearic acid were applied onto the surfaces of coarse part icles of paracetamol and acetylsalicylic acid by continuous multipurpo se melt technology. The effect of melt coating on radial and axial ten sile strength was studied and compared to that of dry mixing of parace tamol and acetylsalicylic acid with fine particles of the excipients. It was found that radial and axial tensile strength were increased to a greater extent with continuous multipurpose melt technology than wit h dry mixing. The reasons for the increased tensile strength associate d with continuous multipurpose melt technology was explained in terms of improved distribution onto the drug particles.