FAT REPLACEMENT OF HODGKIN DISEASE OF BONE-MARROW AFTER CHEMOTHERAPY - REPORT OF 3 CASES

Three cases are presented with fat replacement of Hodgkin disease of b one marrow after chemotherapy. Magnetic resonance imaging on admission demonstrated low-signal intensity of lesions on T1-weighted images an d high-signal intensity on short inversion time inversion-recovery ima ges. Seven lesions were observed, five of which were located in the sp ine and two in the pelvis. All lesions showed reversal of signal inten sities after completion of chemotherapy T1-weighted fat saturation ima ges confirmed the fatty nature of the lesions after treatment. All pat ients had a nodular sclerosis, Hodgkin disease, type 2. One can specul ate as to whether the conversion to fat actually represents a particul arly successful result of chemotherapy.