Multiple myeloma may have extraosseous manifestations in the cranial r
egion, It may be a solitary intracranial tumour without any other sign
s of multiple myeloma, or intracranial disease may be a part of genera
lised disease. as in the present case. Our patient had received chemot
herapy for multiple myeloma for 9 months, with good response, However,
her condition suddenly deteriorated, with signs of increased intracra
nial pressure and a 5-cm-diameter tumour infiltrating the meninges and
brain was found in the left temporal fossa, The radiological diagnosi
s, based on contrast-enhanced CT and angiography was not straightforwa
rd or specific for plasmacytoma, as chemotherapy for the extracranial
disease had been successful. Diseases such as meningioma, metastasis,
lymphoma, chondrosarcoma or haemangioma had to be considered.