REPLICATION OF HERPES-SIMPLEX VIRUS TYPE-1 AND TYPE-2 IN THE MEDULLA OF THE ADRENAL-GLAND AFTER VAGINAL INFECTION OF MICE - BRIEF REPORT

After vaginal infections of mice with neuroinvasive strains of herpes simplex virus type 1 and 2 (HSV-1, HSV-2) virus replicates in the epit helium of the vagina, in the paravaginal ganglia, in the spinal cord a nd finally in the brain and in the adrenal glands. However, viral anti gens could be demonstrated only in the medulla of the adrenal glands b ut not in the cortex, as assessed by immunohistochemistry (IHC). HSV c ould not be isolated from liver, spleen, uterus, and ovaries. This con trasts to the intraperitoneal (i.p) route of infection with replicatio n in different visceral organs including the adrenal gland's cortex.