A SIMPLE-MODEL FOR THE ESTIMATION OF CONGENITAL-MALFORMATION FREQUENCY IN RACIALLY MIXED POPULATIONS

A simple model is proposed, using the method of maximum likelihood to estimate malformation frequencies in racial groups based on data obtai ned from hospital services. This model uses the proportions of racial admixture, and the observed malformation frequency. It was applied to two defects: postaxial polydactyly and cleft lip, the frequencies of w hich are recognizedly heterogeneous among racial groups. The frequenci es estimated in each racial group were those expected for these malfor mations, which proves the applicability of the method.