METAL-ION INTERACTION WITH PENICILLINS .8. EQUILIBRIUM STUDY OF MIXED-LIGAND COMPLEX-FORMATION OF CO(II), NI(II), CU(II) AND ZN(II) WITH AMPICILLIN AND SOME AMINO-ACIDS

Equilibrium study of complex formation of M(2+) ions (M = Co, Ni, Cu a nd Zn) with ampicillin (AH) and aminoacids (B), viz. glycinate, alpha- alaninate, beta-alaninate and aspartate in ternary systems in aqueous solution at 37 degrees C at a fixed ionic strength I = 0.1 mol dm(-3) (NaNO3) indicated the formation of mixed-ligand complexes of the types : M (A)(B), M(A-H)(B), M(A-H)(B)(OH), in addition to the binary M(A) a nd M(B) complexes. Stability of the mixed-ligand complexes were correl ated with the modes of coordination of the ligands.