ACUTE-RENAL-FAILURE IN THE SETTING OF MARROW TRANSPLANTATION

Acute renal failure (ARF) is a common complication of bone marrow tran splantation (BMT) that confers a high mortality rate, There are multip le factors that contribute to ARF in the setting of BMT, and they can be conveniently divided based on time of occurrence, We review the mos t common causes of ARF in the setting of BMT and address prophylaxis a nd treatment issues. Acute renal failure seen within the first 5 days posttransplant can result from tumor lysis syndrome and marrow infusio n toxicity, Within the first month posttransplant, ARF secondary to he patic veno-occlusive disease is a common complication, Late renal fail ure, caused by radiation-induced hemolytic-uremic syndrome and cyclosp orine toxicity, will also be reviewed, In addition, we discuss chronic renal insufficiency resulting from BMT.