EROSION OF POLY(ANHYDRIDE-CO-IMIDES) - A PRELIMINARY MECHANISTIC STUDY

Citation
Jo. Seidel et al., EROSION OF POLY(ANHYDRIDE-CO-IMIDES) - A PRELIMINARY MECHANISTIC STUDY, Journal of applied polymer science, 62(8), 1996, pp. 1277-1283
Citations number
12
Categorie Soggetti
Polymer Sciences
ISSN journal
00218995
Volume
62
Issue
8
Year of publication
1996
Pages
1277 - 1283
Database
ISI
SICI code
0021-8995(1996)62:8<1277:EOP-AP>2.0.ZU;2-N
Abstract
A new class of biodegradable polymers that show promising characterist ics for orthopedic applications was investigated. This study examines aspects underlying the polymer erosion of itylimidoglycine-co-1,6-bis( carboxyphenoxy)hexane] and tylimidoalanine-co-1,6-bis(carboxyphenoxy)h exane]. Copolymer degradation was studied by examining the anhydride b ond hydrolysis and copolymer composition by IR and NMR spectroscopy. H ydrolysis of the anhydride bonds occurred much faster than did the dis solution of the hydrolyzed products, leading to the formation of two d istinct erosion zones. The two erosion zones were observed by light an d scanning electron microscopy with erosion originating at the surface and moving to the center of the polymer samples. (C) 1996 John Wiley & Sons, Inc.