PREPARATION OF DEUTERATED DICLOFENAC FOR USE AS AN INTERNAL STANDARD IN QUANTITATIVE MEASUREMENT BY GAS-CHROMATOGRAPHY NEGATIVE-ION CHEMICAL-IONIZATION MASS-SPECTROMETRY

Authors
LEIS HJ GLEISPACH H WINDISCHHOFER W
Citation
Hj. Leis et al., PREPARATION OF DEUTERATED DICLOFENAC FOR USE AS AN INTERNAL STANDARD IN QUANTITATIVE MEASUREMENT BY GAS-CHROMATOGRAPHY NEGATIVE-ION CHEMICAL-IONIZATION MASS-SPECTROMETRY, Rapid communications in mass spectrometry, 10(13), 1996, pp. 1605-1606
Citations number
6
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
10
Issue
13
Year of publication
1996
Pages
1605 - 1606
Database
ISI
SICI code
0951-4198(1996)10:13<1605:PODDFU>2.0.ZU;2-E
Abstract
A procedure for the preparation of deuterated diclofenac is described, The resulting d(5)-diclofenac was used as an internal standard for qu antitative measurement of the drug. The benefits of deuteration versus oxygen-18 labeling are demonstrated. Enhanced stability of the isotop e label resulted in greater flexibility in sample handling during the work-up steps of plasma samples.