Adjustment of ventilation rates in buildings is widely practised, both
to provide good air quality on a proactive basis and to mitigate air
quality problems associated with occupant complaints. However, both cr
oss-sectional and experimental epidemiological studies have reported m
ixed results and have for the most part failed to establish definitive
relationships between ventilation rates and symptom prevalence or dis
satisfaction with air quality. The difficulties involved in establishi
ng such relationships may be due to a variety of confounding factors w
hich include limitations in study design and interaction effects; diff
iculties in controlling ventilation rates in experimental studies; ina
dequate mixing of supply air in occupied spaces; high source strengths
for some contaminants; dynamic interactions between sources and venti
lation rates that result in increased contaminant emissions; contamina
nt dose-response sensory effects which are log-linear; potential conta
minant generation within ventilation systems themselves; and multifact
orial genesis of sick building symptoms. There is limited evidence to
suggest that ventilation rate increases up to 10 L/s . person may be e
ffective in reducing symptom prevalence and occupant dissatisfaction w
ith air quality and that higher ventilation rates are not effective. B
ecause of complex relationships between ventilation rates, contaminant
levels, and building-related health complaints/dissatisfaction with a
ir quality, the use of ventilation as a mitigation measure for air qua
lity problems should be tempered with an understanding of factors whic
h may limit its effectiveness.