SYNTHESIS AND ANTIMICROBIAL PROPERTIES OF NEW 4-(ALKYLIDENE 2-FURANYL)-2,4-DIHYDRO-3H-1,2,4-TRIAZOLE-3-THIONES AND ANYL)-7H-1,2,4-TRIAZOLO[3,4-B][1,3,4]THIADIAZINES/

A series of 2-furanyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones (2) and aryl-3-(2-furanyl)-7H-1,2,4-triazolo[3,4-b][1,3,4] thiadiazines (3) w ere synthesized. The configuration of 2g was assigned on the basis of H-1-NMR data. Of the new derivatives tested, only 2b, 2g, and 4f were found to be active against Staphylococcus aureus and/or Staphylococcus epidermidis (MIC 125-1.95 mu g/ml), whereas all exhibited varying deg rees of antifungal activity (MIC 25-0.8 mu g/ml).