INCREASE OF PREPROENKEPHALIN MESSENGER-RNA IN THE CAUDAL PART OF PERIAQUEDUCTAL GRAY BY MORPHINE-WITHDRAWAL IN RATS - A QUANTITATIVE IN-SITU HYBRIDIZATION STUDY

Authors
FUKUNAGA Y NISHIDA S INOUE N KISHIOKA S YAMAMOTO H
Citation
Y. Fukunaga et al., INCREASE OF PREPROENKEPHALIN MESSENGER-RNA IN THE CAUDAL PART OF PERIAQUEDUCTAL GRAY BY MORPHINE-WITHDRAWAL IN RATS - A QUANTITATIVE IN-SITU HYBRIDIZATION STUDY, Molecular brain research, 42(1), 1996, pp. 128-130
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
42
Issue
1
Year of publication
1996
Pages
128 - 130
Database
ISI
SICI code
0169-328X(1996)42:1<128:IOPMIT>2.0.ZU;2-Y
Abstract
Effects of morphine withdrawal on the levels of preproenkephalin (PPE) mRNA in the area from lateral to ventrolateral periaqueductal gray (F AG) were studied in rats by quantitative in situ hybridization. PPE mR NA in the rostral FAG was decreased by naloxone-precipitated morphine withdrawal but not affected by spontaneous morphine withdrawal. PPE mR NA in the caudal FAG was increased by both spontaneous and naloxone-pr ecipitated morphine withdrawal.