STEREOCHEMICAL CONGRUENCE OF BAEYER-VILLIGERASES

The enantiomeric bicyclic ketones 1, 3 and the tricyclic ketone 5 unde rgo stereochemically congruent Baeyer-Villiger oxidations with CHMO fr om Acinetobacter sp,, CPMO from Pseudomonas sp, as well as 2,5-DKCMO, 3,6-DKCMO and MO2 from P, putida; in every case the tricyclic ketone 5 is transformed with > 96% ee, N-terminal sequences for the FAD/NADPH linked enzymes from Acinetobacter sp,, Pseudomonas sp, and a novel CHM O from R, coprophilus have high homology with each other but no homolo gy with the FMN/NADH linked enzymes; 2,5-DKCMO and 3,6-DKCMO.