CHARACTERIZATION OF THE HUMAN AND MOUSE CDNAS CODING FOR S100A13, A NEW MEMBER OF THE S100 PROTEIN FAMILY

Here we report the characterization of the human S100A13 cDNA coding f or a novel calcium-binding protein belonging to the S100 protein famil y. The predicted S100A15 protein shows sequence homologies to other S1 00 proteins between 50.5% (to S100A5) and 59.3% (to S100A12). High mRN A amounts were found in skeletal muscle. heart, kidney, ovary, small i ntestine and pancreas. Since twelve S100 genes are clustered on human chromosome 1q21, we determined the chromosomal localization of the hum an S100A13. It co-localizes with S100A1 on the cluster. Furthermore, w e characterized the cDNA sequence coding for the mouse homolog of S100 A13. Similar to the putative human protein, mouse S100A13 is composed of 98 amino acids displaying a homology of 86.7% compared to human S10 0A13. (C) 1996 Academic Press, Inc.