BIOSYNTHESIS OF MARCFORTINE-A

Citation
Ms. Kuo et al., BIOSYNTHESIS OF MARCFORTINE-A, Journal of antibiotics, 49(10), 1996, pp. 1006-1013
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
ISSN journal
00218820
Volume
49
Issue
10
Year of publication
1996
Pages
1006 - 1013
Database
ISI
SICI code
0021-8820(1996)49:10<1006:BOM>2.0.ZU;2-N
Abstract
This report describes the results of a biosynthesis study of marcforti ne A (MA). We report here that MA is derived from methionine, tryptoph an, lysine and two isoprene units the being derived from acetic acid. From the C-13 enrichment pattern of the pipecolic acid moeity further conclude that this unit is derived from lysine via alpha-ketoglutarate . Therefore, we haves accounted for the biogenesis of every carbon ato m of MA and established the biosynthetic pathway for the pipecolic aci d moiety of MA.