Pe. Valensi et al., EFFECTS OF A PURIFIED MICRONIZED FLAVONOID FRACTION ON CAPILLARY FILTRATION IN DIABETIC-PATIENTS, Diabetic medicine, 13(10), 1996, pp. 882-888
Citations number
35
Categorie Soggetti
Endocrynology & Metabolism","Medicine, General & Internal
The objective of the present study was to investigate the effects of a
purified micronized flavonoid fraction (Daflon 500 mg) on the increas
ed capillary filtration of albumin (CFA) which is an early change in t
he microcirculation of patients with diabetes. A placebo controlled tr
ial lasting 30 to 42 days including two equal groups of 20 patients, f
ollowing a 15-day initial placebo run-in phase. The CFA test employed
consisted of injecting albumin labelled with technetium (Tc-99m) intra
venously, applying a venous tourniquet to one arm, and counting the ra
dioactivity on the ipselateral forearm using an external gamma camera.
The disappearance of radioactivity was analysed by means of two param
eters after the tourniquet had been released, i.e. albumin retention (
AR) and the LF/HF index which indicates lymphatic function in intersti
tial protein clearance. All patients included exhibited an increase in
these two indices before the initial placebo run-in phase and at the
end of the run-in period. At the end of the treatment phase, AR had si
gnificantly decreased in the group treated by the flavonoid fraction (
FF) by comparison with the placebo group, and had normalized in 65% of
patients in the FF group, compared with 25% of patients in the placeb
o group (p = 0.010). The LF/HF index normalized in 55% of cases in the
FF group, compared with no patients on placebo (p = 0.00001). This st
udy suggests that the flavonoid fraction tested here can improve and e
ven normalize capillary filtration of albumin in diabetic patients.