PYOGENIC GRANULOMA OF THE TONGUE IN CHRON IC GRAFT-VERSUS-HOST DISEASE

Introduction. The development of pyogenic granuloma of the tongue is r are. We report such a case in a patient with chronic graft-versus-host disease. Case report. A 5-year-old girl was treated with allogenic bo ne marrow transplantation for aplastic anemia. Complications consisted in chronic graft-versus-host disease with cutaneous, mucosal and hepa tic involvement. Seven months later, a voluminous pyogenic granuloma o f the tongue developed on previous erosive lichenoid lesions of chroni c graft-versus-host disease while the patient was under cyclosporin. S urgical resection was done. Relapse occurred and treatment was identic al. Discussion. Six cases of pyogenic granuloma of the oral cavity in chronic graft-versus-host disease have been reported in the literature . Pyogenic granuloma must be considered in tumoral lesion of the oral cavity of patients with chronic graft-versus-host disease. All patient s had erosive lichenoid lesions and were under cyclosporin; its role i n the genesis of these lesions is debated. Treatment relies on surgica l resection confirming the diagnosis.