A. Chakraborty et Bk. Chowdhury, MICROBIAL TRANSFORMATION OF SELECTED CARBAZOLE DERIVATIVES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 35(6), 1996, pp. 617-620
A strain of Pseudomonas aeruginosa and another of Aspergillus fumigatu
s are found to have the ability to degrade carbazole derivatives. Thes
e strains show different specificities for growth on 1- and 3-methylca
rbazoles and accumulate formylcarbazoles as end products in low yields
. Pseudomonas species degrade 1- and 3-formylcarbazoles to the corresp
onding carboxylic acid derivatives which in turn are decarboxylated to
carbazole in high yields. This strain also biotransforms the N-acetyl
carbazoles (8, 9 and 10) and the respective deacetyl-derivatives (7,2
and 11) are obtained in good yields. This study provides an evidence i
n favour of the suggested biotransformation of 3-methylcarbazole to ca
rbazole via 3-formylcarbazole and carbazole-3-carboxylic acid in the p
lants.