We report on a 59-year-old woman presenting with erythema and red, sub
cutaneous nodules degenerating into ulceration involving tissue of the
upper arms, the buttocks, the thighs and breasts. The rare condition
of lupus erythematosus profundus with emphasis on the occurrence of lu
pus mastitis and possible lupus psychosis is discussed. The ulcerating
nodules of lupus erythematosus profundus and the symptoms of psychosi
s were successfully treated with a combined therapy of methylprednisol
one and chloroquine.