GASTRIC-EMPTYING OF SOLIDS IN HUMANS - IMPROVED EVALUATION BY KAPLAN-MEIER PLOTS, WITH SPECIAL REFERENCE TO OBESITY AND GENDER

It has been suggested that obesity is associated with an altered rate of gastric emptying, and that there are also sex differences in gastri c emptying. The results of earlier studies examining gastric emptying rates in obesity and in males and females have proved inconsistent. Th e aim of this study was to investigate the influence of obesity and ge nder on gastric emptying, by extending conventional evaluation methods with Kaplan Meier plots, in order to assess whether these factors hav e to be accounted for when interpreting results of scintigraphic gastr ic emptying tests. Twenty-one normal-weight volunteers and nine obese subjects were fed a standardised technetium-99m labelled albumin omele tte. Imaging data were acquired at 5- and 10-min intervals in both pos terior and anterior projections with the subjects in the sitting posit ion. The half-emptying time, analysed by Kaplan-Meier plot (log-rank t est), were shorter in obese subjects compared to normal-weight subject s and later in females compared to males. Also, the lag-phase and half -emptying time were shorter in obese females than in normal females. T his study shows an association between different gastric emptying rate s and obesity and gender. Therefore, body mass index and gender have t o be accounted for when interpreting results of scintigraphic gastric emptying studies.