Objective: To determine the longitudinal cost of the treatment of pati
ents with breast cancer. Methods: An analysis was performed of 200 wom
en with 205 newly diagnosed breast cancers during 1989 in a health mai
ntenance organization population (US Healthcare, Blue Bell, Pa). Medic
al records and claims data were analyzed for the total costs of medica
l care during the 4-year period after diagnosis. The costs over time w
ere analyzed for clinical stage and use of mammography screening.Resul
ts: The total costs of medical care during the 4-year period after dia
gnosis were strongly related to clinical stage at diagnosis, with high
er total costs for patients with stages III to IV at diagnosis compare
d with patients with stages 0 to II at diagnosis. The cost for all sta
ges of disease declined after years 1 to 2, with the exception of stag
e II, which increased slightly in years 3 to 4. The use of screening m
ammography was associated with a significant decrease in the cost of m
edical care during the 4-year study period. Conclusions: The goal of m
ammography screening programs should be to achieve downstaging to stag
es 0 to I to achieve reduction in breast cancer mortality and to reduc
e the overall consumption of health care resources for the treatment o
f breast cancer. These cost data should be considered within the frame
work of future cost-effective analysis for screening mammography progr
ams.