EFFICACY AND SAFETY OF TRIAMCINOLONE ACETONIDE AQUEOUS NASAL SPRAY INPATIENTS WITH SEASONAL ALLERGIC RHINITIS

Background: In order to accommodate increasing patient preferences, a new aqueous formulation of triamcinolone acetonide nasal spray was dev eloped for the relief of symptoms associated with seasonal and perenni al allergic rhinitis. Objective: This multicenter, randomized, double- blind study was designed to compare the efficacy and safety of once-da ily triamcinolone acetonide aqueous nasal spray (220 mu g/day) with pl acebo in relieving the symptoms of seasonal allergic rhinitis due to r agweed. Methods: One hundred forty patients received either a once dai ly 220-mu g dose of triamcinolone acetonide aqueous nasal spray or pla cebo for 2 weeks. Patients evaluated the severity of seasonal allergic rhinitis symptoms daily for 2 weeks according to a 4-point scale (0 = absent, 1 = mild, 2 = moderate, 3 = severe). Physician and patient gl obal evaluations of overall treatment effectiveness were assessed at t he end of the treatment period. Results: Patients receiving triamcinol one acetonide aqueous nasal spray, 220 mu g/day, had significantly (P < .05) greater improvements in all rhinitis symptoms at weeks 1 and 2 and overall for the 2-week treatment period compared with the placebo group. A significant (P = .006) improvement in the nasal index occurre d as early as 12 hours after the first dose of triamcinolone acetonide aqueous nasal spray. Both patients and physicians reported a greater overall improvement in symptoms for the triamcinolone acetonide aqueou s nasal spray group. There were no differences between the two treatme nt groups in the incidence of adverse events. Conclusions: This study confirmed that a 220-mu g dose of triamcinolone acetonide aqueous nasa l spray, administered once daily for 2 weeks, is well tolerated and re duces effectively the severity of symptoms of seasonal allergic rhinit is due to ragweed.