Painful neuropathy is common in human diabetes. In rats, experimental
diabetes results in altered pain sensitivity. We examined the effect o
f chronic insulin treatment on diabetes-induced hyperalgesia in strept
ozocin diabetic rats. A 20-week period of diabetes resulted in a 62% d
ecrease in paw withdrawal thresholds compared with age-matched normal
rats. Daily injections of insulin progressively reversed mechanical hy
peralgesia to normal values parallel to the correction of hyperglycaem
ia. When the treatment was stopped, mechanical hyperalgesia reappeared
, but never reached the degree of hyperalgesia observed before insulin
treatment, suggesting that indirect mechanisms underlie the effect of
normoglycaemia on nociception. The present data suggest that appropri
ate blood glucose control can help relieve pain in long-term diabetes
through indirect mechanisms.