D-2-TYPE DOPAMINE-RECEPTORS IN POSTMORTEM HUMAN BRAIN SECTIONS FROM NORMAL AND SCHIZOPHRENIC SUBJECTS

The density of the presumed dopamine D-4 receptor ([H-3]YM-09151-2 min us [H-3]raclopride), as well as the densities of the two ligands thems elves were compared in various areas of cerebral tissue from normal ve rsus schizophrenic subjects off or on antipsychotic drugs at the time of death. Using autoradiographic techniques, and analyzing various bra in areas, no differences were found in the density of the D-4 receptor , nor were differences found between the groups, in any brain region, in the amount of bound [H-3]YM-09151-2 or [H-3]raclopride. There were, therefore, no differences in the density of the D-2-type receptors, i ncluding the D-4 receptor, in normal and schizophrenic subjects off or on antipsychotic drugs at the time of death.