QT dispersion calculated from the standard 12-lead ECG has emerged as
an noninvasive measurement of the degree of inhomogeneity in myocardia
l repolarization. The studies evaluating predictive value of QT disper
sion for identification of patients at increased risk for serious vent
ricular arrhythmias and sudden cardiac death have been conducted in mu
ltiple disease states and show promising results. This review focuses
on the conceptual evolution, currently accepted methodology, and clini
cal and research applications of QT dispersion measurements.