ANTIBODIES FROM IMMUNE AFRICAN DONORS WITH A PROTECTIVE EFFECT IN PLASMODIUM-FALCIPARUM HUMAN INFECTION ARE ALSO ABLE TO CONTROL ASEXUAL BLOOD FORMS OF THE PARASITE IN SAIMIRI MONKEYS
J. Gysin et al., ANTIBODIES FROM IMMUNE AFRICAN DONORS WITH A PROTECTIVE EFFECT IN PLASMODIUM-FALCIPARUM HUMAN INFECTION ARE ALSO ABLE TO CONTROL ASEXUAL BLOOD FORMS OF THE PARASITE IN SAIMIRI MONKEYS, Research in immunology, 147(6), 1996, pp. 397-401
We have recently shown that an IgG preparation obtained from immune Af
rican donors was able to control Plasmodium falciparum multiplication
in the blood of Thai patients, but had no inhibitory activity against
the parasite in vitro. The same IgG preparation was passively transfer
red to Saimiri monkeys acutely infected with two different strains of
P. falciparum, one of African origin and the other from French Guyana.
A dose-dependent in vivo inhibition of parasite development was obser
ved with both strains. The results justify the use of Saimiri monkeys
for malaria vaccine trials and permit the introduction of new techniqu
es for screening of candidate antigens for vaccines.