THE EFFICACY AND PHARMACOKINETICS OF LONG-TERM LOW-LEVEL INTRARUMINALADMINISTRATION OF TRICLABENDAZOLE IN BUFFALO WITH INDUCED FASCIOLIASIS

A study was conducted on the pharmacokinetics and therapeutic efficacy of triclabendazole at three low dose rates of 0.5, 1.0 and 1.5 mg/kg body weight in buffaloes experimentally infected with Fasciola giganti ca. The pharmacokinetics were compared with the effects of a single in traruminal dose at 24.0 mg/kg body weight in uninfected buffaloes. At all three dose rates, an equilibrium between the absorption of triclab endazole and the disposition of its metabolites was observed by days 3 and 4 and remained almost unchanged thereafter. Continuous daily dosi ng at 1.5 mg/kg body weight proved to be efficacious against liver flu ke infection in buffaloes.