AN EXTENDED 10-DAY COURSE OF CLOMIPHENE CITRATE (CC) IN WOMEN WITH CC-RESISTANT OVULATORY DISORDERS

Objective: To evaluate the effectiveness of extended duration clomiphe ne citrate (CC) (100 mg for 10 days) as an alternative to complex ovul ation induction strategies for women who fail to ovulate despite stand ard incremental doses of CC of greater than or equal to 150 mg for 5 d ays. Design: Retrospective case series. Setting: University-based infe rtility practice. Patient(s): Thirty women with CC-resistant World Hea lth Organization group II ovulatory disorders. Intervention(s): At lea st one cycle of 100 mg CC from days 3 to 12, Result(s): Fourteen patie nts (47%) ovulated during 31 of their 48 cycles (65%). Five women (17% ) conceived a total of seven singleton pregnancies, including five ter m deliveries and two spontaneous abortions. Weight, body mass index, a nd the presence of hyperandrogenism did not predict responsiveness to the extended duration CC, Side effects were similar to those reported during standard CC treatment. Conclusion(s): An extended 10-day course of CC provides a simple, noninvasive, and inexpensive alternative for a subset of women with ovulatory disorders that are refractory to sta ndard CC treatment.