Acute pulmonary edema after a large air embolus occurring during neuro
surgery is a recognized phenomenon. The authors describe the course of
a 76-year-old man who presented with noncardiogenic pulmonary edema s
hortly after undergoing resection of a high convexity meningioma. Tran
sthoracic Doppler sonography, however, showed no evidence of a large i
ntraoperative emboli; the evidence for ongoing but low-magnitude air e
mbolus included visualization of bone aspiration of irrigant before bo
ne-edge waxing, transient intraoperative declines in end-tidal CO2 ten
sion, and an increase of the fraction of inspired oxygen to maintain a
dequate saturation after removal of the craniotomy flap. There was no
hemodynamic instability noted. The airspace disease was self-limited a
nd resolved on supportive treatment after approximately 1 week, as wou
ld be expected for pulmonary edema caused by a single large intravenou
s air embolus. The authors present this case as the first report of pu
lmonary edema resulting from low-level air embolus occurring during cr
aniotomy. This situation may go unrecognized intraoperatively but can
cause the same significant postoperative morbidity as larger, more eas
ily identified air emboli.