SYNTHESIS OF POLYFUNCTIONALIZED TROGER BASE ANALOGS DERIVED FROM ETHACRIDINE (6,9-DIAMINO-2-ETHOXYACRIDINE)

Authors
TATIBOUET A DEMEUNYNCK M LHOMME J
Citation
A. Tatibouet et al., SYNTHESIS OF POLYFUNCTIONALIZED TROGER BASE ANALOGS DERIVED FROM ETHACRIDINE (6,9-DIAMINO-2-ETHOXYACRIDINE), Synthetic communications, 26(23), 1996, pp. 4375-4395
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
26
Issue
23
Year of publication
1996
Pages
4375 - 4395
Database
ISI
SICI code
0039-7911(1996)26:23<4375:SOPTBA>2.0.ZU;2-Y
Abstract
In the search for chemical probes of DNA conformations, we report an e fficient synthesis of new Troger's Base analogs derived from polyfunct ionalized aminoacridines treated with a stoechiometric amount of forma ldehyde in trifluoroacetic acid. For the more sensitive aminoacridines , the Troger's Bases were obtained by nucleophilic substitution of the chloro group of the ''pre-formed'' corresponding Troger's Base.