SERUM ALPHA(1)-ANTITRYPSIN CONCENTRATION IN DOGS WITH PANNICULITIS

Objective-To measure serum alpha(1)-antitrypsin (alpha(1)AT) concentra tion in dogs with histologically confirmed panniculitis to determine w hether serum deficiency could cause or exacerbate panniculitis in dogs . Design-Cross-sectional, descriptive study. Animals-9 dogs (5 with mu ltiple lesions and 4 with solitary lesions). Procedure-Serum samples w ere obtained by means of cephalic or jugular venipuncture and frozen a t -20 C until assayed. Serum alpha(1)AT concentration was measured by means of radial gel immunodiffusion. Results-In all clogs, serum alpha (1)AT concentration was within the previously established reference ra nge. Clinical Implications-In the small number of dogs studied, pannic ulitis was not associated with serum alpha(1)AT deficiency.