A 4-year-old sexually intact male Standardbred trotter was evaluated f
or left forelimb lameness. A presumptive diagnosis of severe cartilage
damage was made because the horse had a history of infectious arthrit
is involving the left metacarpophalangeal joint. Arthroscopic evaluati
on revealed what was presumed to be a large villonodular lesion. The m
ass was surgically removed, and the horse was treated with procaine pe
nicillin G, trimethoprim-sulfamethoxazole, phenylbutazone, and polysul
fated glycosaminoglycans and eventually returned to racing, Histologic
examination of the mass revealed a bed of granulation tissue covered
with keratinized epithelium. We hypothesize that the lesion developed
secondarily to implantation of epithelial cells into a reactive villon
odular lesion.