AN IMPROVED METHOD FOR THE SYNTHESIS OF N3'-]P5' PHOSPHORAMIDATE OLIGONUCLEOTIDES

Authors
MCCURDY SN NELSON JS HIRSCHBEIN BL FEARON KL
Citation
Sn. Mccurdy et al., AN IMPROVED METHOD FOR THE SYNTHESIS OF N3'-]P5' PHOSPHORAMIDATE OLIGONUCLEOTIDES, Tetrahedron letters, 38(2), 1997, pp. 207-210
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
2
Year of publication
1997
Pages
207 - 210
Database
ISI
SICI code
0040-4039(1997)38:2<207:AIMFTS>2.0.ZU;2-Y
Abstract
A new method for the synthesis of N3'-->P5' phosphoramidate oligonucle otides is demonstrated. This phosphoramidite amine-exchange method gen erates cycle yields in the 92-95% range, and provides overall yields t hat are 3-6 times higher than the previously published oxidative phosp horylation method. Copyright (C) 1996 Elsevier Science Ltd