SYNTHESIS OF A NOVEL ALPHA-GLUCOSIDE OF THE POWERFUL GLUCOSIDASE INHIBITOR 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL VIA ENZYMATIC GLUCOSYLATION OF 5-AZIDO-5-DEOXY-D-FRUCTOPYRANOSE
K. Dax et al., SYNTHESIS OF A NOVEL ALPHA-GLUCOSIDE OF THE POWERFUL GLUCOSIDASE INHIBITOR 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL VIA ENZYMATIC GLUCOSYLATION OF 5-AZIDO-5-DEOXY-D-FRUCTOPYRANOSE, Tetrahedron letters, 38(2), 1997, pp. 225-226
Regio- and stereoselective enzymatic glucosylation of 5-azido-5-deoxy-
D-fructopyranose with the aid of commerically available alpha-glucosid
ase from yeast allows easy access to the corresponding 4-O-alpha-D-glu
copyranosyl derivative of this non-natural ketose. This disaccharide g
ives, in one step, access to y-3-O-alpha-D-glucopyranosyl-2,5-imino-D-
mannitol. Copyright (C) 1996 Elsevier Science Ltd