FIRST ASYMMETRIC-SYNTHESIS OF (2R,3R)-3-AMINO-1-BENZYL-2-METHYLPYRROLIDINE VIA A HIGHLY DIASTEREOSELECTIVE REDUCTIVE ALKYLATION

Authors
HUANG PQ WANG SL ZHENG H FEI XS
Citation
Pq. Huang et al., FIRST ASYMMETRIC-SYNTHESIS OF (2R,3R)-3-AMINO-1-BENZYL-2-METHYLPYRROLIDINE VIA A HIGHLY DIASTEREOSELECTIVE REDUCTIVE ALKYLATION, Tetrahedron letters, 38(2), 1997, pp. 271-272
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
2
Year of publication
1997
Pages
271 - 272
Database
ISI
SICI code
0040-4039(1997)38:2<271:FAO(>2.0.ZU;2-C
Abstract
The first asymmetric synthesis of (2R, 3R)-3-amino-1-benzyl-2-methylpy rrolidine the parent diamine of antipsychotic agent, emonapride, from (S)-malic acid was achieved via a highly diastereroselective reductive alkylation. Copyright (C) 1996 Elsevier Science Ltd