Background. The study was undertaken to quantitate the effects of thor
acoscopic splanchnic nerve resection (SPL) on pain from chronic pancre
atitis. Methods. Patients with chronic pancreatitis pain completed an
analog pain scale before operation and at postoperative visits. Midepi
gastric and left-sided pain was treated with left SPL; right-sided pai
n was treated with right-sided SPL. If pain recurred on the contralate
ral side, the patient underwent contralateral SPL. Results. Fifteen pa
tients underwent SPL. Eleven patients required daily narcotics for rel
ief of pain before operation. Eight patients had unilateral SPL, where
as seven ultimately had a bilateral operation (median follow-up, 18 mo
nths). Fourteen patients had constant pain before operation which decr
eased to a mean of 2.8 attacks per month (p < 0.0001). Before operatio
n, the ''worst pain within last two months'' was 9.1 on pain scab (ran
ge, 0 for no pain to 11 for constant pain). After operation this decre
ased to 5.1 (p < 0.002). ''Current severity'' of pain decreased from 6
.5 before operation to 2.0 after operation (p < 0.0005). The ''amount
pain is interferring with daily activities'' decreased from 7.3 before
operation to 2.3 after operation (p < 0.0001). Seven patients (46%) n
o longer require narcotics and are classified as having had good resul
ts. Five patients (33%) are classified as improved and have had a majo
r reduction in narcotic needs. Three have had no significant pain reli
ef and are classified as having had poor results. Conclusions. Thoraco
scopic SPL offers substantial promise in the therapy of pain from chro
nic pancreatitis.